An enlightened approach
It may be possible to stimulate decayed teeth to repair themselves
Goodbye to all that
Dentistry has too much “drill and fill”, cutting away infected tissue and replacing it with alien, artificial materials. But if work by people such as David Mooney of Harvard University comes to fruition, the days of drill and fill may be numbered. For, as they report in Science Translational Medicine, Dr Mooney and his team have found a surprising way to get dentine, the tissue that underlies a tooth’s enamel coat, to repair itself. They do so by shining a laser beam at it.
Regenerative medicine boils down to the intelligent manipulation of stem cells. A stem cell is one that has the capacity to split asymmetrically so that one daughter remains a stem cell (and can thus go on to perform the same trick) while the other gives birth to a line which proliferates and differentiates into many other sorts of cell. The most famous, and controversial, stem cells are those in early embryos. These can turn into any sort of body cell. Mature tissues such as dentine contain stem cells of more limited capability, which keep up a supply of new specialised cells to replace old ones as they die.
Dr Mooney’s trick is to tickle dentine’s stem cells in a way that encourages them to proliferate and produce more dentine. And that is where the laser comes in. The light it shines creates chemically potent, oxygen-rich molecules such as hydrogen peroxide which go on to activate latent versions of molecules called transforming growth factor–beta 1 (TGF-beta 1). These, in turn, activate dentine’s stem cells and encourage the tissue’s growth.
Dr Mooney and his team have shown that this works in both tissue cultures and actual (rats’) teeth. Moreover, blocking the action of TGF-beta 1 with a drug, or by knocking out the gene that encodes the growth factor’s receptor, stops it happening, which suggests they have understood the mechanism correctly.
This is a preliminary result, and it does not address the question of whether enamel might similarly be repaired. But it is encouraging. Eventually, perhaps, dentists will approach cavities with lasers rather than drills—and the days of fillings will be over.
An enlightened approach
It may be possible to stimulate decayed teeth to repair themselves
Goodbye to all that
Dentistry has too much “drill and fill”, cutting away infected tissue and replacing it with alien, artificial materials. But if work by people such as David Mooney of Harvard University comes to fruition, the days of drill and fill may be numbered. For, as they report in Science Translational Medicine, Dr Mooney and his team have found a surprising way to get dentine, the tissue that underlies a tooth’s enamel coat, to repair itself. They do so by shining a laser beam at it.
Regenerative medicine boils down to the intelligent manipulation of stem cells. A stem cell is one that has the capacity to split asymmetrically so that one daughter remains a stem cell (and can thus go on to perform the same trick) while the other gives birth to a line which proliferates and differentiates into many other sorts of cell. The most famous, and controversial, stem cells are those in early embryos. These can turn into any sort of body cell. Mature tissues such as dentine contain stem cells of more limited capability, which keep up a supply of new specialised cells to replace old ones as they die.
Dr Mooney’s trick is to tickle dentine’s stem cells in a way that encourages them to proliferate and produce more dentine. And that is where the laser comes in. The light it shines creates chemically potent, oxygen-rich molecules such as hydrogen peroxide which go on to activate latent versions of molecules called transforming growth factor–beta 1 (TGF-beta 1). These, in turn, activate dentine’s stem cells and encourage the tissue’s growth.
Dr Mooney and his team have shown that this works in both tissue cultures and actual (rats’) teeth. Moreover, blocking the action of TGF-beta 1 with a drug, or by knocking out the gene that encodes the growth factor’s receptor, stops it happening, which suggests they have understood the mechanism correctly.
This is a preliminary result, and it does not address the question of whether enamel might similarly be repaired. But it is encouraging. Eventually, perhaps, dentists will approach cavities with lasers rather than drills—and the days of fillings will be over.
An enlightened approach
It may be possible to stimulate decayed teeth to repair themselves
Goodbye to all that
Dentistry has too much “drill and fill”, cutting away infected tissue and replacing it with alien, artificial materials. But if work by people such as David Mooney of Harvard University comes to fruition, the days of drill and fill may be numbered. For, as they report in Science Translational Medicine, Dr Mooney and his team have found a surprising way to get dentine, the tissue that underlies a tooth’s enamel coat, to repair itself. They do so by shining a laser beam at it.
Regenerative medicine boils down to the intelligent manipulation of stem cells. A stem cell is one that has the capacity to split asymmetrically so that one daughter remains a stem cell (and can thus go on to perform the same trick) while the other gives birth to a line which proliferates and differentiates into many other sorts of cell. The most famous, and controversial, stem cells are those in early embryos. These can turn into any sort of body cell. Mature tissues such as dentine contain stem cells of more limited capability, which keep up a supply of new specialised cells to replace old ones as they die.
Dr Mooney’s trick is to tickle dentine’s stem cells in a way that encourages them to proliferate and produce more dentine. And that is where the laser comes in. The light it shines creates chemically potent, oxygen-rich molecules such as hydrogen peroxide which go on to activate latent versions of molecules called transforming growth factor–beta 1 (TGF-beta 1). These, in turn, activate dentine’s stem cells and encourage the tissue’s growth.
Dr Mooney and his team have shown that this works in both tissue cultures and actual (rats’) teeth. Moreover, blocking the action of TGF-beta 1 with a drug, or by knocking out the gene that encodes the growth factor’s receptor, stops it happening, which suggests they have understood the mechanism correctly.
This is a preliminary result, and it does not address the question of whether enamel might similarly be repaired. But it is encouraging. Eventually, perhaps, dentists will approach cavities with lasers rather than drills—and the days of fillings will be over.
昨晚11點，發現所有的word檔都被我無權的office 2007改過，讓我動彈不得。
寄檔給hsu ，之後要它貼在mail給我。另外一種可能是到圖書館去轉檔......
看合宜住宅弊案；名嘴一人補一口.....
"非個人、非個案。"姚立民
64號熱，所以又回88號；煮10顆水餃。
也許7-8年前，我用Google 的Alert 功能，找英文的畢業典禮來賓演說新聞。
不過2年之後，我就覺得沒什麼新意，放棄。
今年我在facebook 看到兩位"朋友"的"畢業典禮來賓演說"草稿；國外的，如紐約時報的元主編的，也很有點意思，也可以談談:In First Public Remarks After Firing, Jill Abramson Talks of Resilience。
讀過Tuchman芭芭拉.塔克曼：《從史著論史學》或譯《实践历史》。
她在前言說，兩家名大學的畢業典禮來賓演說，她都不收入，因為它們夠不上"史"的標準，所以無法和本書的文章相提並論。
國內的大學的畢業典禮來賓演說，可能都有錄影，不過我才看過臺灣大學的幾年的實錄。http://hceducation.blogspot.tw/2014/06/2014.html
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午煮水餃20個:晚越南菜，份量多，談11號10人午餐。
kj 來電談： 41號宿舍；朋友創業case；我提議其工廠的改善要著力：瓶頸testing--非只自動化
連絡安國；世堂.....
我今天與吳董事長談話確定東海宿舍41號內部和管線等處理方向。
希望您最近撥空1-2小時給我和設計團隊-----李氏兄弟，
現在確定老哥下月要去歐洲，
所以，請告訴我們您方便的時間和地點，讓我們向您報告。
《出曜經》卷1：「《出曜經》者，婆須密舅法救菩薩之所撰也，集比一千章，立為三十三品，名曰『法句』，錄其本起，繫而為釋，名曰『出曜』。」(CBETA, T04, no. 212, p. 609, b27-29)
An enlightened approach
It may be possible to stimulate decayed teeth to repair themselves May 31st 2014 | From the print edition
Goodbye to all that REGENERATIVE medicine is a field with big ambitions. It hopes, one day, to repair or replace worn-out hearts, livers, kidneys and other vital organs. Many people, though, would settle for a humbler repair—of their teeth.
Dentistry has too much “drill and fill”, cutting away infected tissue and replacing it with alien, artificial materials. But if work by people such as David Mooney of Harvard University comes to fruition, the days of drill and fill may be numbered. For, as they report in Science Translational Medicine, Dr Mooney and his team have found a surprising way to get dentine, the tissue that underlies a tooth’s enamel coat, to repair itself. They do so by shining a laser beam at it.
Regenerative medicine boils down to the intelligent manipulation of stem cells. A stem cell is one that has the capacity to split asymmetrically so that one daughter remains a stem cell (and can thus go on to perform the same trick) while the other gives birth to a line which proliferates and differentiates into many other sorts of cell. The most famous, and controversial, stem cells are those in early embryos. These can turn into any sort of body cell. Mature tissues such as dentine contain stem cells of more limited capability, which keep up a supply of new specialised cells to replace old ones as they die.
Dr Mooney’s trick is to tickle dentine’s stem cells in a way that encourages them to proliferate and produce more dentine. And that is where the laser comes in. The light it shines creates chemically potent, oxygen-rich molecules such as hydrogen peroxide which go on to activate latent versions of molecules called transforming growth factor–beta 1 (TGF-beta 1). These, in turn, activate dentine’s stem cells and encourage the tissue’s growth.
Dr Mooney and his team have shown that this works in both tissue cultures and actual (rats’) teeth. Moreover, blocking the action of TGF-beta 1 with a drug, or by knocking out the gene that encodes the growth factor’s receptor, stops it happening, which suggests they have understood the mechanism correctly.
This is a preliminary result, and it does not address the question of whether enamel might similarly be repaired. But it is encouraging. Eventually, perhaps, dentists will approach cavities with lasers rather than drills—and the days of fillings will be over. - See more at:
Regenerating teeth
An enlightened approach
It may be possible to stimulate decayed teeth to repair themselves
Goodbye to all that
Dentistry has too much “drill and fill”, cutting away infected tissue and replacing it with alien, artificial materials. But if work by people such as David Mooney of Harvard University comes to fruition, the days of drill and fill may be numbered. For, as they report in Science Translational Medicine, Dr Mooney and his team have found a surprising way to get dentine, the tissue that underlies a tooth’s enamel coat, to repair itself. They do so by shining a laser beam at it.
Regenerative medicine boils down to the intelligent manipulation of stem cells. A stem cell is one that has the capacity to split asymmetrically so that one daughter remains a stem cell (and can thus go on to perform the same trick) while the other gives birth to a line which proliferates and differentiates into many other sorts of cell. The most famous, and controversial, stem cells are those in early embryos. These can turn into any sort of body cell. Mature tissues such as dentine contain stem cells of more limited capability, which keep up a supply of new specialised cells to replace old ones as they die.
Dr Mooney’s trick is to tickle dentine’s stem cells in a way that encourages them to proliferate and produce more dentine. And that is where the laser comes in. The light it shines creates chemically potent, oxygen-rich molecules such as hydrogen peroxide which go on to activate latent versions of molecules called transforming growth factor–beta 1 (TGF-beta 1). These, in turn, activate dentine’s stem cells and encourage the tissue’s growth.
Dr Mooney and his team have shown that this works in both tissue cultures and actual (rats’) teeth. Moreover, blocking the action of TGF-beta 1 with a drug, or by knocking out the gene that encodes the growth factor’s receptor, stops it happening, which suggests they have understood the mechanism correctly.
This is a preliminary result, and it does not address the question of whether enamel might similarly be repaired. But it is encouraging. Eventually, perhaps, dentists will approach cavities with lasers rather than drills—and the days of fillings will be over.
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